Checkpoint Controls and Cancer, Vol. 1: Reviews and Model Systems
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Checkpoint Controls and Cancer, Vol. 1: Reviews and Model Systems

Intracellular checkpoint controls constitute a network of signal transduction pathways that protect cells from external stresses and internal errors by means of cell cycle arrest, DNA repair, or apoptosis. Failure of this machinery can lead to embryonic death, genetic diseases, and cancer. In Checkpoint Controls and Cancer, Volume 1: Reviews and Model Systems, Axel H. Schönthal, PhD, marshals a prestigious panel of researchers workin...

Checkpoint Controls and Cancer, Vol. 2: Activation and Regulation Protocols
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Checkpoint Controls and Cancer, Vol. 2: Activation and Regulation Protocols

Intracellular checkpoint controls constitute a network of signal transd- tion pathways that protect cells from external stresses and internal errors. Ext- nal stresses can be generated by the continuous assault of DNA-damaging agents, such as environmental mutagens, ultraviolet (UV) light, ionizing radiation, or the reactive oxygen species that can arise during normal cellular metabolism. In response to any of these assaults on the i...