Chagas Disease: Prevalence, Diagnosis and Treatment Options

(Parasites and Parasitic Diseases)

Chagas Disease: Prevalence, Diagnosis and Treatment Options Author Sandra R. Wall
File size 3.75MB
Year 2017
Pages 157
Language English
File format PDF
Category Animals

Book Description:

In Chagas Disease: Prevalence, Diagnosis and Treatment Options, the authors begin reviewing the characterization of American trypanosomiasis, or Chagas Disease, noting that although the disease has become less prevalent in recent decades, it is estimated that 8-10 million people are currently infected. Next, authors present a study wherein the dynamics of Trypanosoma cruzi infection (which causes Chagas disease) were mathematically modeled. This model assumed three clinical stages of the disease; acute, chronic indeterminate, and chronic with determinate pathology. Following this, cysteine proteases, ergosterol metabolic pathways, thiol-dependent mechanisms (trypanothione reductase), glycolytic pathways, trans-sialidase enzymes, the transport and metabolism of polyamines, and examples from literature are described in the context of therapeutic targets. The book goes on to discuss the history of nifurtimox and benznidazole, two drugs used in an effort combat Chagas disease. Additionally


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