New Developments in the Pathogenesis of Rheumatoid Arthritis

59ba0d37e20e0.jpg Author Lazaros I. Sakkas
Isbn 9789535129691
File size 10MB
Year 2017
Pages 150
Language English
File format PDF
Category Fitness

Book Description:

This volume is dedicated to the pathogenesis of rheumatoid arthritis (RA). MicroRNAs, part of epigenetic mechanisms, which also include DNA methylation, and histone modification, as well as microbiota, the composition of microbes in body cavities, also appear to influence arthritis and are discussed in this book.

The pathogenesis of rheumatoid arthritis (RA) is incompletely understood. HLA class II alleles and T cells have been implicated for many years. The discovery of anticitrullinated peptide antibodies (ACPAs), along with the effectiveness of biological treatments targeting cytokines, such as TNF-?, IL-6, and also T cells and B cells, reinforced the pathogenetic role of the respective factors. ACPAs, induced by cigarette smoking and periodontitis in individuals with HLA-DRB1 shared epitope, appear to be autoantigens that initiate the inflammatory immune response in RA.

 

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