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Medical Genetics in the Clinical Practice of ORL

Experts in otorhinolaryngology as well as medical genetics have contributed their reviews to this comprehensive compilation. Introductory chapters deal with basic genetics followed by chapters devoted to specific disorders. The gamut of otorhinolaryngological diseases from both adult and pediatric practice is covered. Included are common disorders such as hearing loss, cleft lip and palate, and thyroid cancers as well as further chap...

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AR Signaling in Human Malignancies: Prostate Cancer and Beyond

The notion that androgens and androgen receptor (AR) signaling are the hallmarks of prostate cancer oncogenesis and disease progression is generally well accepted. What is more poorly understood is the role of AR signaling in other human malignancies. This Special Issue of Cancers initially reviews the role of AR in advanced prostate cancer, and then explores the potential importance of AR signaling in other epithelial malignancies. ...

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The Neutrophils: New Outlook for Old Cells (3rd Edition)

This is a third edition of the popular book, which presents an overview of the most recent findings in the biology of neutrophils. These cells are critically important for protection against bacterial and viral infections and have been recently demonstrated to be a major contributor to tumor associated immune suppression. In addition, neutrophils represent a unique model for studying fundamental questions of cellular biochemistry and...

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Physiologic and Pathologic Angiogenesis: Signaling Mechanisms and Targeted Therapy

The purpose of this book is to highlight novel advances in the field and to incentivize scientists from a variety of fields to pursue angiogenesis as a research avenue. This book will become a source of inspiration and novel ideas for all. Blood vessel formation and maturation to capillaries, arteries, or veins is a fascinating area which can appeal to multiple scientists, students, and professors alike. Angiogenesis is relevant to m...

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Breast Cancer: Focusing Tumor Microenvironment, Stem cells and Metastasis

This book covers topics such as characteristics of breast cancer cells, molecular tumor classification methods, in vitro cancer models, breast cancer and microenvironment, breast cancer stem cells, gene regulation in breast cancer, and mechanism of breast cancer cell interaction, invasion as well as metastasis. The book will serve as a good guide for the scientists, researchers and educators in the field. The book includes chapters w...

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Cigarette Smoking : Health Effects and Challenges for Tobacco Control

Tobacco smoking is a major public health issue worldwide. It is responsible for many preventable diseases, contributes to a large number of premature deaths and accounts for enormous economic costs. The chapters in this book review a variety of topics related to the sociodemographic characteristics of tobacco consumers, promotion and merchandising of tobacco products and health consequences of smoking. It also reviews the mechanisms ...

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Pauline Jewett: A Passion for Canada

Although Judith McKenzie deals with Jewett's childhood and university years, much of this insightful story is devoted to her public life as a Member of Parliament for the federal Liberal Party and the New Democratic Party and as a university president. President of Simon Fraser University from 1974 to 1978, she was the first woman to be appointed president of a public coeducational post-secondary institution in Canada. Jewett faced m...

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Cancer Genetics and Genomics for Personalized Medicine

This book covers almost all fields of cancer genetics and genomics for personalized medicine. Targeted therapy, or precision medicine, or personalized medicine is becoming a standard treatment for many diseases, including cancer. However, how much do we know about the personalized medicine approach? This lucid book helps undergraduate and graduate students, professional researchers, and clinicians to better understand the key concept...

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Improving Palliative Care for Cancer

This book examines the barriers—scientific, policy, and social—that keep those in need from getting good palliative care. In our society’s aggressive pursuit of cures for cancer, we have neglected symptom control and comfort care. Less than one percent of the National Cancer Institute’s budget is spent on any aspect of palliative care research or education, despite the half million people who die of cancer each year and the larger nu...